<i>In vivo</i> behavior of untreated and compressed concentrated growth factors as biomaterials in rabbits

To characterize concentrated growth factors (CGFs) in vivo, we examined the degradation of implanted CGF rabbits. Untreated (U-CGF) and compressed (C-CGF) were subcutaneously into dorsum. Histological analyses showed that U-CGF C-CGF induced very few inflammatory cells subsequently degraded with dendritic invasion granulation tissue. The histopathologically remained for longer term than U-CGF. Aggregated CD31+ RAM11+ appeared around CGF. number macrophages blood vessels CGF-implanted groups was greater sham group. There more group We by 4 weeks enhanced angiogenesis dendritically branching new capillaries. Therefore, can be clinically applied as a biomaterial inducing angiogenesis.